Why Work for City of Hope
City of Hope is one of over 53 comprehensive cancer centers in the nation, the highest designation possible from the National Cancer Institute. In the 2021 fiscal year, City of Hope was awarded more than $184 million in research grants.
City of Hope is recognized among the nation's top 10 "Best Hospitals" for cancer, according to U.S. News & World Report's annual rankings, marking the 16th consecutive year we have been distinguished as one of the nation's elite cancer hospitals. U.S. News also singled out our institution as “high-performing” in lung, colon, prostate and ovarian cancer surgery.
City of Hope’s nursing team has achieved Magnet® recognition from the American Nurses Credentialing Center due to our commitment to outstanding health care delivery and patient outcomes. Only 9% of all hospitals nationwide have earned Magnet recognition.
City of Hope is a founding member of the National Comprehensive Cancer Network, meaning our research and treatment protocols advance care throughout the nation.
City of Hope has earned the highest rating — four stars — from the nation’s leading watchdog, Charity Navigator. The four-star rating reflects City of Hope’s sound fiscal management and financial growth and stability.
We were recently awarded the highest level of accreditation by the American College of Surgeons Commission on Cancer for our exceptional level of cancer care, “Three-Year With Commendation.” This is the second consecutive time that we have received this prestigious rating.
We were the first to administer CAR T cell therapy locally in the brain through direct injection to the tumor site and/or through infusion in the ventricular system.
We were the first to offer CAR T trials targeting CD123 in acute myeloid leukemia.
We were the first to use CAR T cell therapy to treat patients with the rare disease blastic plasmacytoid dendritic cell neoplasm.
By offering exquisite care, conducting innovative research and championing vital education concerning topics of cancer and diabetes, our experts draw practical benefits from the mysteries of science and work to save and change lives. In short, we turn hope into reality.
A record of innovation
Numerous breakthrough cancer drugs, including Herceptin, Erbitux, Rituxan and Avastin, are based on technology pioneered by City of Hope and are saving lives worldwide.
Millions of people with diabetes benefit from synthetic human insulin, developed through research conducted at City of Hope.
City of Hope was a pioneer in bone marrow and stem cell transplants — and our program is now one of the largest, most successful programs of its kind in the U.S. We have performed more than 18,000 bone marrow and stem cell transplants.
Surgeons at City of Hope have performed more than16,000 robotic procedures for prostate, kidney, colon, liver, bladder, gynecologic, oral and other cancers.
Speed, efficiency and collaboration
Our research facilities set us apart. We have not one, but three manufacturing facilities on campus that manufacture both biologic and chemical compounds that meet strict GMP (good manufacturing practice) standards. This infrastructure helps us quickly turn breakthrough discoveries into lifesaving therapies.
City of Hope holds more than 450 patent portfolios and submits nearly 50 applications per year to the Food and Drug Administration (FDA)for investigational new therapies. These numbers are exceptionally large for an organization of City of Hope’s size.
Beckman Research Institute of City of Hope was the first of five Beckman Institutes in the United States, which together have fueled scientific advances for more than a generation.
City of Hope conducts more than 800 clinical trials annually, enrolling more than 5,000 patients.
Science that is saving lives
City of Hope researchers are investigating ways to harness the body’s natural defenses to fight cancer, an approach known as immunotherapy. One approach strikes a dual blow — shutting off a gene that promotes cancer while stimulating the immune system to act — in an effort to fight lymphoma and melanoma, as well as brain, ovarian and prostate cancers. Other studies are focused on engaging every stage of the immune response to defeat breast cancer.
City of Hope and Translational Genomics Research Institute (TGen), a leading biomedical research institute, formed an alliance to make precision medicine a reality for patients. This alliance enables both institutes to complement each other’s strengths, with TGen’s genomic insights augmenting the level of care available to City of Hope patients.
Because life after cancer treatment can present both physical and emotional challenges, City of Hope creates a bridge between treatment and ongoing support. The Center for Cancer Survivorship provides specialized follow-up care and education for survivors of pediatric, prostate and breast cancers. The resulting research is helping physicians understand the long-term effects of cancer and its treatment — influencing how care is delivered today at City of Hope and beyond.
Beyond the study of cancer
By investigating the molecular mechanisms of diabetes complications, City of Hope scientists are helping develop new treatments for them. They also are studying the use of blood stem cell transplantation to reboot the immune system in type 1 diabetes, an autoimmune disease.
City of Hope is a national leader in islet cell transplantation, which has the potential to reverse type 1 diabetes. In addition, we provide islet cells for research at other institutions throughout the U.S.
City of Hope scientists pioneered the application of blood stem cell transplants to treat patients with HIV and AIDS-related lymphoma. Our researchers used a new form of gene therapy to achieve the first long-term persistence of anti-HIV genes in patients with AIDS-related lymphoma. This treatment ultimately may cure not only lymphoma, but also HIV/ AIDS, and our researchers are now expanding their studies with a new clinical trial.
For information on a specific trial, call 626-218-1133.
Philanthropic support makes it all possible
City of Hope is powered by philanthropy. It was launched in the firm belief that all of us have the potential to change the fate of individuals, even as we improve medical care overall.
“There is no profit in curing the body if, in the process, we destroy the soul.” Those words were spoken by Samuel H. Golter, one of our early leaders, and they remain the credo that guides City of Hope’s approach to patient care. We are committed to treating the whole person, not only by providing the best medical care possible, but also by providing that care in an atmosphere of kindness and compassion.
Year after year, foundations, philanthropists, business leaders, global corporations, small businesses and hundreds of thousands of other caring individuals of all ages contribute generously to support the lifesaving work of City of Hope.
Many professional sports organizations have supported City of Hope, including the Los Angeles Dodgers, the Los Angeles Kings, Major League Soccer’s Chivas USA and the National Football League.
Since the modern era of City of Hope began in the 1970s, we have developed an international reputation for fundamental studies on immunology, receptors, epigenetics, siRNA, DNA repair, signal transduction, metabolism, and other aspects of molecular and cell biology.
Today, City of Hope is a leader in clinical and translational research, most notably in antibody-based therapy, CAR T cell therapy and bone marrow transplant approaches. Over the last 20 years, significant research has also been accomplished in population-based studies.