The bench-to-bedside-to-bench organization of the PROMT program is singular and not replicated elsewhere.
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-funded Diabetes Prevention Risk Omics Metabolism and Therapy of Diabetes (PROMT) Interdisciplinary Training Program provides two years of clinically relevant education and training to students from traditionally underrepresented backgrounds.
The program is designed for students with analytic skills who desire top-flight, innovative training in the physiology and pathophysiology of diabetes and metabolism that is based on a foundation of fundamental basic science, hypothesis testing, drug identification and development and clinical trials.
As such, the bench-to-bedside-to-bench organization of the PROMT program is unique with a combined basic plus translational focus. Through the PROMT program, students at City of Hope have the structure and facilities to participate in the entire process of bringing new therapies online for the care and cure of diabetes and other metabolic diseases.
Central to the PROMT program mission is the integration of all program activities in order to tie together basic molecular research, state-of-the-art genomics and single cell sequencing technologies, bioinformatics research and science with drug development and clinical medicine.
Graduates will have the necessary skills and motivation to identify and overcome barriers to translating discoveries into practice for the betterment of individuals with diabetes and metabolic disease and their complications.
Predoctoral students enter the PROMT program after completing two years at the Irell & Manella Graduate School of Biological Sciences. The PROMT Ph.D. is accredited by the accrediting agency WASC Senior College and University Commission.
Faculty members are committed to recruiting a diverse group of students and making every effort to guarantee their success. Outstanding candidates from underrepresented groups with degrees emphasizing analytical training who have an interest in diabetes and metabolism as a career are encouraged to apply.
Predoctoral T32 Application
Following matriculation into the Irell & Manella Graduate School of Biological Sciences, interested applicants should identify and choose a thesis mentor from the PROMT faculty, usually following several lab rotations. After the thesis mentor and student develop the applicant’s thesis project and training plan, the applicant should then complete the program application (below) at the end of the fall semester of year two. Recruitment committee members will then request an interview. The Recruitment and Program Executive committees will make the admission decisions.
Prospective candidates must be U.S. citizens or permanent residents. Preference will be given to prospective candidates from underrepresented groups. Successful completion of the two-year Irell & Manella Graduate School of Biologic Sciences (IMGS) core curriculum is required to be eligible for the PROMT program.
- PROMT T32 application form
- List of names and contact information of three references
- Mentor letter of support
- City of Hope IMGS academic transcript (first two years)
The PROMT T32 program will enroll 2 students per year and train these students to be leaders in the vanguard of transitional and clinician research. PROMT graduates will be poised to overcome the scourges of diabetes and metabolic diseases. Under the direction of a primary mentor, co-mentor and clinical partners, students will be immersed in a rich, didactic environment of cross-disciplinary translational research.
- Structured education and training
- Individualized career development
- Didactic courses and educational opportunities within and beyond the program
- Focused and quality training in responsible and transparent research
- Rigorous training in scientific method, data analysis and scientific writing
- Ongoing internal and external monitoring of student progress and mentor performance
- One-of-a-kind access to fresh human endocrine organs, especially pancreata, islets and beta cells
- Access to fresh and biobanked human endocrine, exocrine and vascular tissues, and immune cells
- Multiple on-campus Food and Drug Administration-approved current Good Manufacturing Practice (cGMP) centers for the production of cell and noncell biologic therapies to treat diabetes and metabolic diseases and associated complications
Accepted students will begin the PROMT program in the third year of IMGS education. Specific requirements included:
- PROMT required courses (see below)
- Perform diabetes research from years three onwards.
- Participate in journal clubs and seminars during training.
- Attend and present research at the annual PROMT retreat in years three onwards.
- Years 1 and 2: IMGS Core classes (see the IMGS handbook) and qualifying examination
- Year 3: PROMT courses: BIOSCI 685. Advanced Topics in Diabetes: Therapeutic Targets and the Drug Development Pipeline; Diabetes Special Emphasis Translational Internship; Stress Management and Resilience Workshop; Effective Science Communication Workshop; BIOSCI 690. Advanced Topics in Diabetes and Metabolic Disease
- Year 4: PROMT courses: BIOSCI 570. Rigor and Reproducibility; BIOSCI 712. Diabetes and Dysfunctional Metabolism Journal Club; Diabetes Special Emphasis Translational Internship; Effective Science Communication; Public Science Communication
- Year 5: Diabetes Research and Thesis Defense
The PROMT T32 program is funded by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases and supplemented by City of Hope to provide two years of support, including free tuition and a competitive stipend and benefits.
All PROMT faculty mentors have established laboratories resources and financial support to host and mentor PROMT predoctoral students. Generous travel support is also provided for students to attend a national/international scientific meeting annually and to present their research findings.
Duarte, CA 91010
Diversity And Inclusion
At City of Hope, we believe that diversity is an integral part of who we are and what we do. Since our origins in 1913, we have been a welcoming place for people of all backgrounds. Our diverse community helps us provide culturally competent education and training inspiring patient confidence in our entire institution.