Xiaohua Xu, Ph.D.
Staff Scientist, Cancer Genetics and Epigenetics
2004, Ph.D., Tottori University, Japan
1997, Bachelors of Science, Fuzhou University,China
2011 - Present, Staff Scientist, Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope
2011 - 2011, Associate Research Scientist, Department of Therapeutic Radiology, Yale University
2008 - 2010, Postdoctoral research associate, Department of Therapeutic Radiology, Yale University
2005 - 2007, Postdoctoral research fellow, Department of Structural Biology, Stanford University
1997 - 2001, Research assistant, Institute of Biotechnology Fuzhou University, China
2001 - 2004, Japanese government (Monbusho) scholarship
Li M*., Xu X*., Chang ZW*., Zheng l. et al. RECQ5 facilitates chromatin remodeling via SUMO2-PCNA to prevent transcription-replication conflict. Nat. Commun. 9(1):2706. doi: 10.1038/ s41467-018-05236-y *co-1st author
Xu X., Wang JT., Li M., Liu Y. (2016) TIMELESS suppresses the accumulation of aberrant CDC45-MCM2-7-GINS replicative helicase complexes on human chromatin. J. Biol. Chem. 291, 22544-22558
Li M., *Pokharel S., *Wang JT., *Xu X., Liu Y. (2015) RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability. Nat. Commun. 6:6720. doi: 10.1038/ncomms7720 *co-2nd author
Wang J., Xu X., Alontaga A., Chen y., Liu Y. (2014) Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction. Cell Rep. pii: S2211-1247
Hansen JE., Chan G., Liu Y., Hegan DC., Dalal S., Dray E., Kwon Y., Xu Y., Xu X. et al (2012). Targeting cancer with a lupus autoantibody. Sci Transl Med. 4,157ra142
Machwe A., Karale R., Xu X., Liu Y., Orren D.K. (2011) The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holiday junctions to functional replication forks. Biochemistry. 50, 6774-6788
Li M., Xu X., Liu Y. (2011) The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability. Mol Cell Biol. 31, 2090-2099
Xu X*., Rochette PJ*. et al. (2009) MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. EMBO J. 28, 3005-3014 *co-1st author
Aygün O., Xu X., Liu Y., Takahashi H. et al. (2009) Direct inhibition of RNA polymerase II transcription by RECQL5. J. Biol. Chem. 284, 23197-23203
Xu X., Liu Y. (2009) Dual DNA unwinding activities of the human Rothmund-T homson Syndrome protein, RECQ4. EMBO J. 28, 568-577
Xu X., Wang S. et al. (2007) The periplasmic bacterial molecular chaperone SurA adapts its structure to bind peptides in alternate conformations to assert a sequence preference for aromatic residues. J. Mol. Biol. 373, 367-381
Xu X., Azakami H. et al. (2004) P-domain and lectin site are involved in the chaperone function of Saccharomyces cerevisiae calnexin homologue (Cne1p). FEBS Lett. 570, 155-160
Xu X., Kanbara K. et al. (2004) Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue. J. Biochem (Tokyo). 135, 615-618
Xu X., Kashima O. et al. (2004) Structural and functional properties of chicken lysozyme fused serine-rich hetapeptides at C-terminus. Biosci. Biotechnol. Biochem. 68, 1273-1278
Begum S., Saito A., Xu X. et al. (2003) Improved functional properties of the ovoinhibitor by conjugating with galactomannan. Biosci. Biotechnol. Biochem. 67, 1897-1902
Xu X., Li R. et al. (2002) Quantification of cholesterol in foods using non-aqueous capillary electrophoresis. J Chromatogr. B Biomed. Sci. Appl. 768, 369-373
Chen G.R., Xu X. et al. (2001) Fractionation of Corynebacterium pekinense AS 1.299 phage subtypes by anion-exchange chromatography. J. Virol. Methods 95, 11-17
Zhang R., Xu X. et al. (2000) An assay for angiotensin-converting enzyme using capillary zone electrophoresis. Anal. Biochem. 280, 286-290